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Info page for variable 8118142 (#3992)

Internal ID: 3992
Label in dataset: 8118142
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Accession Number: NM_000594
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Gene Information: Entrez ID 7124
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Gene Symbol TNF, tumor necrosis factor
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miRBase: Accession -na-
Chromosome location:
Chromosome Location
6 31,543,349 (sense)
6_apd_hap1 2,859,026 (sense)
6_cox_hap2 3,052,965 (sense)
6_dbb_hap3 2,828,890 (sense)
6_mann_hap4 2,886,233 (sense)
6_mcf_hap5 2,923,055 (sense)
6_qbl_hap6 2,836,987 (sense)
6_ssto_hap7 2,874,150 (sense)
KEGG Pathways:
Pathway Description
04010 MAPK signaling pathway
04060 Cytokine-cytokine receptor interaction
04210 Apoptosis
04350 TGF-beta signaling pathway
04612 Antigen processing and presentation
04620 Toll-like receptor signaling pathway
04621 NOD-like receptor signaling pathway
04622 RIG-I-like receptor signaling pathway
04640 Hematopoietic cell lineage
04650 Natural killer cell mediated cytotoxicity
04660 T cell receptor signaling pathway
04664 Fc epsilon RI signaling pathway
04920 Adipocytokine signaling pathway
04930 Type II diabetes mellitus
04940 Type I diabetes mellitus
05010 Alzheimer's disease
05014 Amyotrophic lateral sclerosis (ALS)
05140 Leishmaniasis
05142 Chagas disease
05144 Malaria
05146 Amoebiasis
05310 Asthma
05322 Systemic lupus erythematosus
05330 Allograft rejection
05332 Graft-versus-host disease
05410 Hypertrophic cardiomyopathy (HCM)
05414 Dilated cardiomyopathy
Gene Ontology:
GOID Evidence Ontology Description(GO Term)
GO:0000060 IDAInferred from Direct Assay BPBiological Process protein import into nucleus, translocation
GO:0000122 IEAInferred from Electronic Annotation BPBiological Process negative regulation of transcription from RNA polymerase II promoter
GO:0000187 IDAInferred from Direct Assay BPBiological Process activation of MAPK activity
GO:0001775 IEAInferred from Electronic Annotation BPBiological Process cell activation
GO:0001819 IDAInferred from Direct Assay BPBiological Process positive regulation of cytokine production
GO:0001934 IDAInferred from Direct Assay BPBiological Process positive regulation of protein amino acid phosphorylation
GO:0002037 IEAInferred from Electronic Annotation BPBiological Process negative regulation of L-glutamate transport
GO:0002439 IMPInferred from Mutant Phenotype BPBiological Process chronic inflammatory response to antigenic stimulus
GO:0002740 IDAInferred from Direct Assay BPBiological Process negative regulation of cytokine secretion involved in immune response
GO:0002876 IEAInferred from Electronic Annotation BPBiological Process positive regulation of chronic inflammatory response to antigenic stimulus
GO:0002925 IEAInferred from Electronic Annotation BPBiological Process positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0009615 IDAInferred from Direct Assay BPBiological Process response to virus
GO:0007165 IEAInferred from Electronic Annotation BPBiological Process signal transduction
GO:0006006 IEAInferred from Electronic Annotation BPBiological Process glucose metabolic process
GO:0006916 IDAInferred from Direct Assay BPBiological Process anti-apoptosis
GO:0006917 IDAInferred from Direct Assay BPBiological Process induction of apoptosis
GO:0006919 IDAInferred from Direct Assay BPBiological Process activation of caspase activity
GO:0006927 IDAInferred from Direct Assay BPBiological Process transformed cell apoptosis
GO:0009612 IEAInferred from Electronic Annotation BPBiological Process response to mechanical stimulus
GO:0006954 IDAInferred from Direct Assay BPBiological Process inflammatory response
GO:0006959 IEAInferred from Electronic Annotation BPBiological Process humoral immune response
GO:0019722 IEAInferred from Electronic Annotation BPBiological Process calcium-mediated signaling
GO:0007275 IEAInferred from Electronic Annotation BPBiological Process multicellular organismal development
GO:0009887 IEAInferred from Electronic Annotation BPBiological Process organ morphogenesis
GO:0050796 IDAInferred from Direct Assay BPBiological Process regulation of insulin secretion
GO:0050830 IEAInferred from Electronic Annotation BPBiological Process defense response to Gram-positive bacterium
GO:0008285 IEAInferred from Electronic Annotation BPBiological Process negative regulation of cell proliferation
GO:0008624 IDAInferred from Direct Assay BPBiological Process induction of apoptosis by extracellular signals
GO:0008625 IEAInferred from Electronic Annotation BPBiological Process induction of apoptosis via death domain receptors
GO:0042493 IEAInferred from Electronic Annotation BPBiological Process response to drug
GO:0009651 TASTraceable Author Statement BPBiological Process response to salt stress
GO:0010888 NASNon-traceable Author Statement BPBiological Process negative regulation of lipid storage
GO:0010940 TASTraceable Author Statement BPBiological Process positive regulation of necrotic cell death
GO:0016481 IDAInferred from Direct Assay BPBiological Process negative regulation of transcription
GO:0030198 IEAInferred from Electronic Annotation BPBiological Process extracellular matrix organization
GO:0030730 IDAInferred from Direct Assay BPBiological Process sequestering of triglyceride
GO:0031622 ISSInferred from Sequence or Structural Similarity BPBiological Process positive regulation of fever
GO:0032582 IDAInferred from Direct Assay BPBiological Process negative regulation of gene-specific transcription
GO:0032715 IDAInferred from Direct Assay BPBiological Process negative regulation of interleukin-6 production
GO:0032722 IDAInferred from Direct Assay BPBiological Process positive regulation of chemokine production
GO:0032729 IEAInferred from Electronic Annotation BPBiological Process positive regulation of interferon-gamma production
GO:0032755 IEAInferred from Electronic Annotation BPBiological Process positive regulation of interleukin-6 production
GO:0032800 IDAInferred from Direct Assay BPBiological Process receptor biosynthetic process
GO:0033209 IMPInferred from Mutant Phenotype BPBiological Process tumor necrosis factor-mediated signaling pathway
GO:0044130 IEAInferred from Electronic Annotation BPBiological Process negative regulation of growth of symbiont in host
GO:0034116 IDAInferred from Direct Assay BPBiological Process positive regulation of heterotypic cell-cell adhesion
GO:0042346 IDAInferred from Direct Assay BPBiological Process positive regulation of NF-kappaB import into nucleus
GO:0043066 IDAInferred from Direct Assay BPBiological Process negative regulation of apoptosis
GO:0043122 IDAInferred from Direct Assay BPBiological Process regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043123 IDAInferred from Direct Assay BPBiological Process positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043193 IDAInferred from Direct Assay BPBiological Process positive regulation of gene-specific transcription
GO:0043525 IEAInferred from Electronic Annotation BPBiological Process positive regulation of neuron apoptosis
GO:0045071 IDAInferred from Direct Assay BPBiological Process negative regulation of viral genome replication
GO:0045080 IDAInferred from Direct Assay BPBiological Process positive regulation of chemokine biosynthetic process
GO:0045429 IDAInferred from Direct Assay BPBiological Process positive regulation of nitric oxide biosynthetic process
GO:0045599 NASNon-traceable Author Statement BPBiological Process negative regulation of fat cell differentiation
GO:0045670 IEAInferred from Electronic Annotation BPBiological Process regulation of osteoclast differentiation
GO:0045840 IEAInferred from Electronic Annotation BPBiological Process positive regulation of mitosis
GO:0045941 IDAInferred from Direct Assay BPBiological Process positive regulation of transcription
GO:0045944 IEAInferred from Electronic Annotation BPBiological Process positive regulation of transcription from RNA polymerase II promoter
GO:0045994 IEAInferred from Electronic Annotation BPBiological Process positive regulation of translational initiation by iron
GO:0046325 IEAInferred from Electronic Annotation BPBiological Process negative regulation of glucose import
GO:0046330 IEAInferred from Electronic Annotation BPBiological Process positive regulation of JNK cascade
GO:0048661 IDAInferred from Direct Assay BPBiological Process positive regulation of smooth muscle cell proliferation
GO:0050715 IDAInferred from Direct Assay BPBiological Process positive regulation of cytokine secretion
GO:0050806 IEAInferred from Electronic Annotation BPBiological Process positive regulation of synaptic transmission
GO:0050901 IDAInferred from Direct Assay BPBiological Process leukocyte tethering or rolling
GO:0050995 IDAInferred from Direct Assay BPBiological Process negative regulation of lipid catabolic process
GO:0051023 IEAInferred from Electronic Annotation BPBiological Process regulation of immunoglobulin secretion
GO:0051044 IDAInferred from Direct Assay BPBiological Process positive regulation of membrane protein ectodomain proteolysis
GO:0051091 IDAInferred from Direct Assay BPBiological Process positive regulation of transcription factor activity
GO:0051092 IDAInferred from Direct Assay BPBiological Process positive regulation of NF-kappaB transcription factor activity
GO:0051222 IEAInferred from Electronic Annotation BPBiological Process positive regulation of protein transport
GO:0051384 IDAInferred from Direct Assay BPBiological Process response to glucocorticoid stimulus
GO:0051798 IEAInferred from Electronic Annotation BPBiological Process positive regulation of hair follicle development
GO:0060555 IDAInferred from Direct Assay BPBiological Process induction of necroptosis by extracellular signals
GO:0060557 IDAInferred from Direct Assay BPBiological Process positive regulation of vitamin D biosynthetic process
GO:0060559 IDAInferred from Direct Assay BPBiological Process positive regulation of calcidiol 1-monooxygenase activity
GO:0060664 IEAInferred from Electronic Annotation BPBiological Process epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060693 IEAInferred from Electronic Annotation BPBiological Process regulation of branching involved in salivary gland morphogenesis
GO:0061048 IDAInferred from Direct Assay BPBiological Process negative regulation of branching involved in lung morphogenesis
GO:0070265 IDAInferred from Direct Assay BPBiological Process necrotic cell death
GO:0070374 NASNon-traceable Author Statement BPBiological Process positive regulation of ERK1 and ERK2 cascade
GO:0005886 EXPInferred from Experiment CCCellular Component plasma membrane
GO:0001891 ISSInferred from Sequence or Structural Similarity CCCellular Component phagocytic cup
GO:0005576 IEAInferred from Electronic Annotation CCCellular Component extracellular region
GO:0005887 IDAInferred from Direct Assay CCCellular Component integral to plasma membrane
GO:0005615 IDAInferred from Direct Assay CCCellular Component extracellular space
GO:0009897 ISSInferred from Sequence or Structural Similarity CCCellular Component external side of plasma membrane
GO:0009986 IDAInferred from Direct Assay CCCellular Component cell surface
GO:0045121 IDAInferred from Direct Assay CCCellular Component membrane raft
GO:0055037 ISSInferred from Sequence or Structural Similarity CCCellular Component recycling endosome
GO:0005515 IPIInferred from Physical Interaction MFMolecular Function protein binding
GO:0005125 IDAInferred from Direct Assay MFMolecular Function cytokine activity
GO:0005164 IDAInferred from Direct Assay MFMolecular Function tumor necrosis factor receptor binding
GO:0042802 IDAInferred from Direct Assay MFMolecular Function identical protein binding
GO:0010843 IDAInferred from Direct Assay MFMolecular Function promoter binding
GO:0016563 IDAInferred from Direct Assay MFMolecular Function transcription activator activity
GO:0016564 IDAInferred from Direct Assay MFMolecular Function transcription repressor activity
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Correlation Browser: Daniel Sachse, Sjur Reppe, Kåre Gautvik - 2013.

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